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By the end of this section, you will be able to:
  • Identify the cardinal signs of inflammation
  • List the body’s response to tissue injury
  • Explain the process of tissue repair
  • Discuss the progressive impact of aging on tissue
  • Describe cancerous mutations’ effect on tissue

Tissues of all types are vulnerable to injury and, inevitably, aging. In the former case, understanding how tissues respond to damage can guide strategies to aid repair. In the latter case, understanding the impact of aging can help in the search for ways to diminish its effects.

Tissue injury and repair

Inflammation is the standard, initial response of the body to injury. Whether biological, chemical, physical, or radiation burns, all injuries lead to the same sequence of physiological events. Inflammation limits the extent of injury, partially or fully eliminates the cause of injury, and initiates repair and regeneration of damaged tissue. Necrosis , or accidental cell death, causes inflammation. Apoptosis is programmed cell death, a normal step-by-step process that destroys cells no longer needed by the body. By mechanisms still under investigation, apoptosis does not initiate the inflammatory response. Acute inflammation resolves over time by the healing of tissue. If inflammation persists, it becomes chronic and leads to diseased conditions. Arthritis and tuberculosis are examples of chronic inflammation. The suffix “-itis” denotes inflammation of a specific organ or type, for example, peritonitis is the inflammation of the peritoneum, and meningitis refers to the inflammation of the meninges, the tough membranes that surround the central nervous system

The four cardinal signs of inflammation—redness, swelling, pain, and local heat—were first recorded in antiquity. Cornelius Celsus is credited with documenting these signs during the days of the Roman Empire, as early as the first century AD. A fifth sign, loss of function, may also accompany inflammation.

Upon tissue injury, damaged cells release inflammatory chemical signals that evoke local vasodilation    , the widening of the blood vessels. Increased blood flow results in apparent redness and heat. In response to injury, mast cells present in tissue degranulate, releasing the potent vasodilator histamine    . Increased blood flow and inflammatory mediators recruit white blood cells to the site of inflammation. The endothelium lining the local blood vessel becomes “leaky” under the influence of histamine and other inflammatory mediators allowing neutrophils, macrophages, and fluid to move from the blood into the interstitial tissue spaces. The excess liquid in tissue causes swelling, more properly called edema. The swollen tissues squeezing pain receptors cause the sensation of pain. Prostaglandins released from injured cells also activate pain neurons. Non-steroidal anti-inflammatory drugs (NSAIDs) reduce pain because they inhibit the synthesis of prostaglandins. High levels of NSAIDs reduce inflammation. Antihistamines decrease allergies by blocking histamine receptors and as a result the histamine response.

Questions & Answers

difference between seminiferous tubules and ejaculatory duct
Muhammad Reply
tell me the answer boss
Musibi
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Agemo Reply
what is azygous vein
Karan Reply
Sir muscle contraction ka topic kis part m milega
sonugora Reply
Sir muscle contraction ka topic kis part m milega
sonugora Reply
what is manipulated
Ambika Reply
life circle of RBC and the life circle of WBC.
Yemi Reply
RBC 120days
Zeph
RBC 120days and WBC 10-12days
sai
what is cardiac vascular system
Hari
what is anatomy?
Md Reply
what is manipulated
Ambika
anatomy is the branch of medical science which deal with the gross structure of body or organ
Ambika
note shoulder joint
jagadeesh
what is cardiovascular system
Hari
what is manipulated
Ambika
anatomical position
Ambika
?
Ambika
Scapula
sonugora
Study of internal structures
sonugora
the system of heart and vessels
Manar
what is collar Bone?
jagadeesh
positive feedback mechanism
Sirimala Reply
what is immunology
Riya Reply
immunology is a branch of medicine that study's the body immune system
SAMUEL
Immunology This is the study of specific and non-specific resistance of the body against infection i.e. the study of the immune response of a host to a foreign substance, which includes study of various reactions which are induced in the body by introduction of a substance.
Kaluki
what is role of elimination need like fluid and also stools
Munmun Reply
bone
Vijay
what is joint pain
Vijay
is the physical suffering caused by illness or injury of the joint
malulu
pls can someone describe shock,types ,pathophysiology and treatment
Isaac
this is what I'm thinking "After taking out everything the body needs, the bowel then expels the leftover waste."
isaiah
I think elimination also helps in the continuation of the digestive system because if the unwanted fluids and stools does not come out of the system it can create a problem in the digestive. system resulting in diseases.
Martha
shock is a condition whereby the circulating system is unable to get enough blood and oxygen to vital organs like the brain,heart,eye,kidney and others.
Martha
causing depression of those organs.
Martha
there are 2 classification of shock. primary shock: this occurs immediately after injury due emotional stimulus or pain.example hearing a bad news,sudden obstruction of airway.sudden heart attack. secondary shock :it occurs when primary shock is delayed
Martha
types of shock syncope (faint) oligaemic or hyppvovaemic shock. Anaphylactic shock. neurogenic/ physical shock septic sock catdiogenic shock.
Martha
What is the difference between dna duplication and chromosomes duplication?
to help you identify the human body parts to help you live a healthy life the study of Anatomy helps one to work in any health sector
sophia Reply
okay.
what is the function of the mitochondrial in the cell
Vida Reply
define and explain the synovial membrane
Mahmudu Reply

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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