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By the end of this section, you will be able to:
  • Describe the structure and features of the nuclear membrane
  • List the contents of the nucleus
  • Explain the organization of the DNA molecule within the nucleus
  • Describe the process of DNA replication

The nucleus is the largest and most prominent of a cell’s organelles ( [link] ). The nucleus is generally considered the control center of the cell because it stores all of the genetic instructions for manufacturing proteins. Interestingly, some cells in the body, such as muscle cells, contain more than one nucleus ( [link] ), which is known as multinucleated. Other cells, such as mammalian red blood cells (RBCs), do not contain nuclei at all. RBCs eject their nuclei as they mature, making space for the large numbers of hemoglobin molecules that carry oxygen throughout the body ( [link] ). Without nuclei, the life span of RBCs is short, and so the body must produce new ones constantly.

The nucleus

This figure shows the structure of the nucleus. The nucleolus is inside the nucleus, surrounded by the chromatin and covered by the nuclear envelope.
The nucleus is the control center of the cell. The nucleus of living cells contains the genetic material that determines the entire structure and function of that cell.

Multinucleate muscle cell

This micrograph shows a muscle cell with multiple nuclei.
Unlike cardiac muscle cells and smooth muscle cells, which have a single nucleus, a skeletal muscle cell contains many nuclei, and is referred to as “multinucleated.” These muscle cells are long and fibrous (often referred to as muscle fibers). During development, many smaller cells fuse to form a mature muscle fiber. The nuclei of the fused cells are conserved in the mature cell, thus imparting a multinucleate characteristic to mature muscle cells. LM × 104.3. (Micrograph provided by the Regents of University of Michigan Medical School © 2012)

View the University of Michigan WebScope at (External Link) to explore the tissue sample in greater detail.

Red blood cell extruding its nucleus

This set of micrographs shows a red blood cell extruding its nucleus. In the left panel, the nucleus is partially extruded from the red blood cell and in the right panel, the nucleus is completely extruded from the cell.
Mature red blood cells lack a nucleus. As they mature, erythroblasts extrude their nucleus, making room for more hemoglobin. The two panels here show an erythroblast before and after ejecting its nucleus, respectively. (credit: modification of micrograph provided by the Regents of University of Michigan Medical School © 2012)

View the University of Michigan WebScope at (External Link) to explore the tissue sample in greater detail.

Inside the nucleus lies the blueprint that dictates everything a cell will do and all of the products it will make. This information is stored within DNA. The nucleus sends “commands” to the cell via molecular messengers that translate the information from DNA. Each cell in your body (with the exception of germ cells) contains the complete set of your DNA. When a cell divides, the DNA must be duplicated so that the each new cell receives a full complement of DNA. The following section will explore the structure of the nucleus and its contents, as well as the process of DNA replication.

Organization of the nucleus and its dna

Like most other cellular organelles, the nucleus is surrounded by a membrane called the nuclear envelope    . This membranous covering consists of two adjacent lipid bilayers with a thin fluid space in between them. Spanning these two bilayers are nuclear pores. A nuclear pore    is a tiny passageway for the passage of proteins, RNA, and solutes between the nucleus and the cytoplasm. Proteins called pore complexes lining the nuclear pores regulate the passage of materials into and out of the nucleus.

Questions & Answers

Its a fusion of bones where the bones becomes flexible or stiff.. Its a kind of arthritis
rumana Reply
what is ankylosis
Adam Reply
master gland Kon si h
kajal Reply
Pituitary gland
pituitary gland because it give harmonies and control other gland
glands often secrete hormones which play an important role in maintaining homeostasis.
pituitary gland
pituitary gland is master gland because it present in biran and secrtehormones and play other gland of human body and function its gland so that also called master gland.
pituitary glandis the master gland of our body
how do you study for A&P? lab and lecture?
Aubrey Reply
depends how your lab exams and lecture exams are structured. but either way, you want to study two weeks before any of the exams. study in a way that you would be teaching it to someone. lec is mostly physio. and a lil' anatomy. lab is all anatomy and motion- so memorization is key.
record the lectures in both cases. read the lessons for that class day. have questions. go to office hours. this will help you in A&P- if anything the teacher would give you a little bit of points for making so much of an effort
When one is suffering from motion sickness what area of the brain may trigger emesis?
amy Reply
that is the sign of stroke. if the patient have a stroke. the left side of body is weakness, the affected right of cerebrum but if right side of the body is weakness surely in left side!
thank you sooo much bro
Fatima Reply
Fatima hw a u
any one elaborate fr me foramens of the skull and features which they transmit
icant undrestand plz
zahruuzh Reply
try to read I hop you will understand
state and explain 20 radiology uses
what are chemicals in anatomy and physiology?
Mike Reply
what can I do to find it easy for me in anatomy and physiology course
study up on the basics of the periodic chart, learn bones and muscles attachments, and learn muscles. Those take the longest to memorize. After that it should be a little easier.
what are the two types of body cells
Jennifer Reply
what is malnutrition
malnutrition refers to faulty nutrition resulting from malabsorption,poor diet or overeating. Sometimes too these food do not contain all the six food nutrients in their right proportion.
thank you
Will u be malnourished?
What's the difference between radiology and radiology
Nothing! Radiology it means the study or using of radiation in medical science it can be 1.diagnose or treatment diagnosed radiology! x- ray. ultrasound. ct-scan. mammogram. MRI. 2. treatmen- radiation oncology, like Cobalt 60. and nuclear medicine
what is X-ray?
X-ray is type of light that make it possible to see inside any object. as human body
How the nervous system develops
ayiesher Reply
From the cells at the back of an embryo
breifly explain anatomy of thorax
Hadiza Reply
How many region the rib is divided
how many bon of human being
how to study for the skeletal system
and anatomy
I really need sources immediately
I printed out all the different bones. Put them in the see through protective sheaths and got dry erase markers. I could right on them and erase to help me learn to spell the names of markings and bones.
Or go to a book store, Barnes and Noble(doesn't have to be this) and they have coloring books for anatomy. $16. Really helpful.
okay thanks and are what study tools you use to study the materials and get a better understanding
*what are
I prefer diagrams, pictures that lay out each step with the information in each step. For Example: how action potential creates muscles to move. A pictured diagram gives me a better understanding of how each piece plays a role in each step of the process.
Also for basics, such as memorizing vocab. Flash cards are great. Don't become discouraged if you don't get them all right the first times through. The more you go through them, your brain will remember pieces of information from each and help you to pull out the information 😉
okay thanks
what is the functions of the lips in human
Momboi Reply
could I say sensation?
for protection
Lips assist in speech and eating
Too many easy questions. Which bones are the axial and appendicular? What are the abbreviations for TEE, TTE, AED, A-Mode, B-Mode, and LTH? What is the difference between hypothalamus and thalamus? Where is the parathyroid located? How many True Ribs do we have?
Sovilace Reply
Transesophageal echocardiography Transthoracic Echocardiography automated external defibrillator brightnees mode Los Hermanos Taverna
what is anatomy
okello Reply
anatomy is scientific study of body structures and how they relate to each other

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