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By the end of this section, you will be able to:
  • Describe the obstacles that sperm must overcome to reach an oocyte
  • Explain capacitation and its importance in fertilization
  • Summarize the events that occur as a sperm fertilizes an oocyte

Fertilization occurs when a sperm and an oocyte (egg) combine and their nuclei fuse. Because each of these reproductive cells is a haploid cell containing half of the genetic material needed to form a human being, their combination forms a diploid cell. This new single cell, called a zygote    , contains all of the genetic material needed to form a human—half from the mother and half from the father.

Transit of sperm

Fertilization is a numbers game. During ejaculation, hundreds of millions of sperm (spermatozoa) are released into the vagina. Almost immediately, millions of these sperm are overcome by the acidity of the vagina (approximately pH 3.8), and millions more may be blocked from entering the uterus by thick cervical mucus. Of those that do enter, thousands are destroyed by phagocytic uterine leukocytes. Thus, the race into the uterine tubes, which is the most typical site for sperm to encounter the oocyte, is reduced to a few thousand contenders. Their journey—thought to be facilitated by uterine contractions—usually takes from 30 minutes to 2 hours. If the sperm do not encounter an oocyte immediately, they can survive in the uterine tubes for another 3–5 days. Thus, fertilization can still occur if intercourse takes place a few days before ovulation. In comparison, an oocyte can survive independently for only approximately 24 hours following ovulation. Intercourse more than a day after ovulation will therefore usually not result in fertilization.

During the journey, fluids in the female reproductive tract prepare the sperm for fertilization through a process called capacitation    , or priming. The fluids improve the motility of the spermatozoa. They also deplete cholesterol molecules embedded in the membrane of the head of the sperm, thinning the membrane in such a way that will help facilitate the release of the lysosomal (digestive) enzymes needed for the sperm to penetrate the oocyte’s exterior once contact is made. Sperm must undergo the process of capacitation in order to have the “capacity” to fertilize an oocyte. If they reach the oocyte before capacitation is complete, they will be unable to penetrate the oocyte’s thick outer layer of cells.

Contact between sperm and oocyte

Upon ovulation, the oocyte released by the ovary is swept into—and along—the uterine tube. Fertilization must occur in the distal uterine tube because an unfertilized oocyte cannot survive the 72-hour journey to the uterus. As you will recall from your study of the oogenesis, this oocyte (specifically a secondary oocyte) is surrounded by two protective layers. The corona radiata    is an outer layer of follicular (granulosa) cells that form around a developing oocyte in the ovary and remain with it upon ovulation. The underlying zona pellucida    (pellucid = “transparent”) is a transparent, but thick, glycoprotein membrane that surrounds the cell’s plasma membrane.

Questions & Answers

thank you sooo much bro
Fatima Reply
Fatima hw a u
any one elaborate fr me foramens of the skull and features which they transmit
icant undrestand plz
zahruuzh Reply
try to read I hop you will understand
state and explain 20 radiology uses
what are chemicals in anatomy and physiology?
Mike Reply
what can I do to find it easy for me in anatomy and physiology course
study up on the basics of the periodic chart, learn bones and muscles attachments, and learn muscles. Those take the longest to memorize. After that it should be a little easier.
what are the two types of body cells
Jennifer Reply
what is malnutrition
malnutrition refers to faulty nutrition resulting from malabsorption,poor diet or overeating. Sometimes too these food do not contain all the six food nutrients in their right proportion.
thank you
Will u be malnourished?
What's the difference between radiology and radiology
Nothing! Radiology it means the study or using of radiation in medical science it can be 1.diagnose or treatment diagnosed radiology! x- ray. ultrasound. ct-scan. mammogram. MRI. 2. treatmen- radiation oncology, like Cobalt 60. and nuclear medicine
what is X-ray?
X-ray is type of light that make it possible to see inside any object. as human body
How the nervous system develops
ayiesher Reply
From the cells at the back of an embryo
breifly explain anatomy of thorax
Hadiza Reply
How many region the rib is divided
how many bon of human being
how to study for the skeletal system
and anatomy
I really need sources immediately
I printed out all the different bones. Put them in the see through protective sheaths and got dry erase markers. I could right on them and erase to help me learn to spell the names of markings and bones.
Or go to a book store, Barnes and Noble(doesn't have to be this) and they have coloring books for anatomy. $16. Really helpful.
okay thanks and are what study tools you use to study the materials and get a better understanding
*what are
I prefer diagrams, pictures that lay out each step with the information in each step. For Example: how action potential creates muscles to move. A pictured diagram gives me a better understanding of how each piece plays a role in each step of the process.
Also for basics, such as memorizing vocab. Flash cards are great. Don't become discouraged if you don't get them all right the first times through. The more you go through them, your brain will remember pieces of information from each and help you to pull out the information 😉
okay thanks
what is the functions of the lips in human
Momboi Reply
could I say sensation?
for protection
Lips assist in speech and eating
Too many easy questions. Which bones are the axial and appendicular? What are the abbreviations for TEE, TTE, AED, A-Mode, B-Mode, and LTH? What is the difference between hypothalamus and thalamus? Where is the parathyroid located? How many True Ribs do we have?
Sovilace Reply
Transesophageal echocardiography Transthoracic Echocardiography automated external defibrillator brightnees mode Los Hermanos Taverna
what is anatomy
okello Reply
anatomy is scientific study of body structures and how they relate to each other
Are there other functions of the nucleolus apart from synthesis of RNA and formation of ribosomes
Peninah Reply
plays a role in cell response to stress
what is angle of auscultation
Bryan Reply
Anatomy which is the study of the human body structure has a couple of reasons it is been studied It helps to discover genetic disease cytology And histology which is the study of tissues Physiology is the study of function of the human cells It helps to know how the different body part works Its helps to know how part of the brain works And lastly It gives the essential to understand more about anatomy
Stephen Reply
describe the external features of a spinal cord
okoche Reply
Spinal nerves emerge in pairs, one from each side of the spinal cord along its length. The cervical nerves form a plexus (a complex interwoven network of nerves—nerves converge and branch). The cervical enlargement is a widening in the upper part of the spinal cord (C 4–T 1). Nerves that extend in
Hormones regulate certain target cell responses. These can include which of the following?
Nazareth Reply
describe the external features of spinal cord

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