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By the end of this section, you will be able to:
  • Explain the mechanism of action of diuretics
  • Explain why the differential permeability or impermeability of specific sections of the nephron tubules is necessary for urine formation

The major hormones influencing total body water are ADH, aldosterone, and ANH. Circumstances that lead to fluid depletion in the body include blood loss and dehydration. Homeostasis requires that volume and osmolarity be preserved. Blood volume is important in maintaining sufficient blood pressure, and there are nonrenal mechanisms involved in its preservation, including vasoconstriction, which can act within seconds of a drop in pressure. Thirst mechanisms are also activated to promote the consumption of water lost through respiration, evaporation, or urination. Hormonal mechanisms are activated to recover volume while maintaining a normal osmotic environment. These mechanisms act principally on the kidney.

Volume-sensing mechanisms

The body cannot directly measure blood volume, but blood pressure can be measured. Blood pressure often reflects blood volume and is measured by baroreceptors in the aorta and carotid sinuses. When blood pressure increases, baroreceptors send more frequent action potentials to the central nervous system, leading to widespread vasodilation. Included in this vasodilation are the afferent arterioles supplying the glomerulus, resulting in increased GFR, and water loss by the kidneys. If pressure decreases, fewer action potentials travel to the central nervous system, resulting in more sympathetic stimulation-producing vasoconstriction, which will result in decreased filtration and GFR, and water loss.

Decreased blood pressure is also sensed by the granular cells in the afferent arteriole of the JGA. In response, the enzyme renin is released. You saw earlier in the chapter that renin activity leads to an almost immediate rise in blood pressure as activated angiotensin II produces vasoconstriction. The rise in pressure is sustained by the aldosterone effects initiated by angiotensin II; this includes an increase in Na + retention and water volume. As an aside, late in the menstrual cycle, progesterone has a modest influence on water retention. Due to its structural similarity to aldosterone, progesterone binds to the aldosterone receptor in the collecting duct of the kidney, causing the same, albeit weaker, effect on Na + and water retention.

Cardiomyocytes of the atria also respond to greater stretch (as blood pressure rises) by secreting ANH. ANH opposes the action of aldosterone by inhibiting the recovery of Na + by the DCT and collecting ducts. More Na + is lost, and as water follows, total blood volume and pressure decline. In low-pressure states, ANH does not seem to have much effect.

ADH is also called vasopressin. Early researchers found that in cases of unusually high secretion of ADH, the hormone caused vasoconstriction (vasopressor activity, hence the name). Only later were its antidiuretic properties identified. Synthetic ADH is still used occasionally to stem life-threatening esophagus bleeding in alcoholics.

Questions & Answers

name the 5 layers of skin
Monika Reply
stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, stratum corneum
those are the layers of epidermis,, then we have the dermis which has got two layers that is papillary dermis and reticular dermis.. beneath the dermis we have the hypodermis( subcutaneous layer) which is not considered as a layer of skin
what's a feedback
ivhil Reply
is the information or comment about something that one have done
may be you mean negative or positive feedback mechanism... in general, they mean body response its changes by hormones
what is endocrin?
Asim Reply
why should there be an inhibition to the process of gastric production in the intestinal phase
endocrine is a system through which the secretions of cell directly poured into blood.
why should there be an inhibition to the process of gastric production in the intestinal
Gloria Reply
what is a stimuli
Emily Reply
environment factor that cause a cell to respond
name the two types of melanin
Laila Reply
deference between RNA and DNA
.DNA stands for Deoxyribonucleic Acid. The sugar portion of DNA is 2-Deoxyribose.RNA stands for Ribonucleic Acid.  The sugar portion of RNA is Ribose.2.The helix geometry of DNA is of B-Form (A or Z also present).The helix geometry of RNA is of A-Form.3.DNA is a double-stranded molecule consisting o
DNA consists of nucleotide but RNA consists of nucleoside DNA is double standard but RNA is single standard.In DNA at the nitrogen bases adinine,guanine,cytocin and thymine is present but in case of RNA instead of thymine uracil is present.
what are rdna
what is a heart
walker Reply
A heart is an organ in the circulatory system that pumps blood throughout the systemic regions
what is anatomy
Anatomy is the study of internal and external structures and the relationship among body parts. (the study of structure).
what is the physiology of the heart
guys help me with a pathophysiology of asthma
asthma is a lungs related disorder in which there is difficulty in breathing due to some allergic factors, their is inflamation of alveoli of respiratory part of lungs.also decreases the surface area.
what is meaning of brain strock and its types?
the pathophysiology of asthma is complex and involves airway inflammation and bronchial hyperresponsiveness pathogenesis of asthma
skin infection please explain
Hamza Reply
what is malignant melanoma
Akon Reply
cancerous cells 🙄
yes benign is non-cancerous malignant is cancerous.
that's a simple way of explaining it however you're different processes like mitosis etc a person can be at risk for developing cancer etc
you can tell by an unusual growth of a mole, or change in size coloration with melanoma. which is abnormal growth of your squamous cells.
Types of wandering connective tissues
Hassan Reply
what are the meaning of skin
study of external structure of human body is known as anatomy
what is Tau?
Vicki Reply
what is sliva
Saqlain Reply
what is gross
Kiran Reply

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