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Reabsorption and secretion in the pct

The renal corpuscle filters the blood to create a filtrate that differs from blood mainly in the absence of cells and large proteins. From this point to the ends of the collecting ducts, the filtrate or forming urine is undergoing modification through secretion and reabsorption before true urine is produced. The first point at which the forming urine is modified is in the PCT. Here, some substances are reabsorbed, whereas others are secreted. Note the use of the term “reabsorbed.” All of these substances were “absorbed” in the digestive tract—99 percent of the water and most of the solutes filtered by the nephron must be reabsorbed. Water and substances that are reabsorbed are returned to the circulation by the peritubular and vasa recta capillaries. It is important to understand the difference between the glomerulus and the peritubular and vasa recta capillaries. The glomerulus has a relatively high pressure inside its capillaries and can sustain this by dilating the afferent arteriole while constricting the efferent arteriole. This assures adequate filtration pressure even as the systemic blood pressure varies. Movement of water into the peritubular capillaries and vasa recta will be influenced primarily by osmolarity and concentration gradients. Sodium is actively pumped out of the PCT into the interstitial spaces between cells and diffuses down its concentration gradient into the peritubular capillary. As it does so, water will follow passively to maintain an isotonic fluid environment inside the capillary. This is called obligatory water reabsorption, because water is “obliged” to follow the Na + ( [link] ).

Substances reabsorbed and secreted by the pct

This diagram shows the different substances that are secreted and reabsorbed by the proximal collecting tubule. Arrows show the direction of the movement of the substance.

More substances move across the membranes of the PCT than any other portion of the nephron. Many of these substances (amino acids and glucose) use symport mechanisms for transport along with Na + . Antiport, active transport, diffusion, and facilitated diffusion are additional mechanisms by which substances are moved from one side of a membrane to the other. Recall that cells have two surfaces: apical and basal. The apical surface is the one facing the lumen or open space of a cavity or tube, in this case, the inside of the PCT. The basal surface of the cell faces the connective tissue base to which the cell attaches (basement membrane) or the cell membrane closer to the basement membrane if there is a stratified layer of cells. In the PCT, there is a single layer of simple cuboidal endothelial cells against the basement membrane. The numbers and particular types of pumps and channels vary between the apical and basilar surfaces ( [link] ). A few of the substances that are transported with Na + (symport mechanism) on the apical membrane include Cl , Ca ++ , amino acids, glucose, and PO 4 3 MathType@MTEF@5@5@+=feaagyart1ev2aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLnhiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr4rNCHbGeaGqiVu0Je9sqqrpepC0xbbL8F4rqqrFfpeea0xe9Lq=Jc9vqaqpepm0xbba9pwe9Q8fs0=yqaqpepae9pg0FirpepeKkFr0xfr=xfr=xb9adbaqaaeGaciGaaiaabeqaamaabaabaaGcbaGaaeiuaiaab+eadaqhaaWcbaGaaGinaaqaaiaaiodacqGHsislaaaaaa@3A2D@ . Sodium is actively exchanged for K + using ATP on the basal membrane. Most of the substances transported by a symport mechanism on the apical membrane are transported by facilitated diffusion on the basal membrane. At least three ions, K + , Ca ++ , and Mg ++ , diffuse laterally between adjacent cell membranes (transcellular).

Questions & Answers

Differentiate between pharmacist and apothecary
adanoor Reply
What is metatarsal
Ndotenyin Reply
bone of the foot is known as metatarsal
Patrick
yes 👆 right
Sneha
metatarsal (foot bone).....👍
Rishi
what is the meaning for cadavers
Malar
yes metatarsal are foot bone
Rakiya
the term "mental" pertain to which of the following a. chin b.navel c. ear d. nose e. skull
cris Reply
a
Lina
chin
Sneha
hi
Mohamed
skull
Monica
skull
Peter
chin
Kelly
skull
Juma
skull
Gul
skull
Laraib
skull
anwaar
skull
Nirmala
skull
Tessmol
chin
Derrick
mental chin nerve
Katarzyna
e. skull
Jennifer
skull
prince
e. skull
Natasha
It's not skull but chin
mwango
the skull
Rakiya
what are the three many components of the lymphatic system?
Milica Reply
those are...... organ, tissue and blood capillary or vessals
Juma
anatomical terms and use them appropriatly in the language of anatomy of anterior body landmarks
Teody Reply
what is human anatomy?
rascal Reply
lts stady structured human body's
Sa
what is the study of how the body functions?
Bright
What is human anatomy
Sherifat
human antomy is the body of structure
Malar
is the study of human body
Rakiya
what is abdomipelvic cavity?
david Reply
Includes all organs within the abdomen(stomach,intestines) and those from the pelvic region hence the name... abdomipelvic
Maureen
where can we find the short bones
Chidi Reply
Carpal bones are examples of short bones
Dara
what is blood supply
Chidi
on upper limb and lower limb
Juma
carpal bones
Priya
during pregnancy which would more increase size the mothers abdominal or pelvic cavity?
Nurmalyn Reply
pelvic cavity I think
Priya
What is anatomical position
Nwoye
pelvic
Maureen
@ Nwoye... when standing erect, feet parallel, arms hanging at the sides with palms facing forward
Maureen
The pelvic cavity
Rakiya
pelvic
Malar
define the main directional terms of the body
cris Reply
during physical exercise respiratory rate increace two student are discussing the mechanisms involved. student A claim they are positive feedback and student B claim negative feedback do you agree with student A or B and why
cris
what is the physiology of circulation
Chidi
please I mean the physiology of criculation
Chidi
blood flow refers to the movement of blood through the vessels from arteries to the capillaries and then to the veins
Laraib
the heart&the lungs
Rakiya
during pregnancy, which would more size the mother's abdominal or pelvic cavity? explain
cris Reply
list and define the three plane of devision of the body
cris
complete the following statements using correct directional terms for human being. 1. the navel is________to the nose 2. the heart is______to the breastbone(sternum) 3 the ankle is______to the knee 4 the ear is______to the eyes.
cris
1. superior 2. posterior 3. superior 4. lateral
Mnm
anterior fuerior
Chidi
inferior medial posterior lateral we
Susan
name the system of the body and its function
cris Reply
11 system are human body 1.integumentary system 2. skeletal system 3. muscular system 4. nervous system 5. endocrine system 6. cardiovascular system 7. lymphatic system 8. respiratory system 9. digestive system 10. urinary system 11. reproductive system male and female.
Vineeta
during pregnancy, which would more size the mother's abdominal or pelvic cavity? explain
cris
how the body maintain hormeostasis in terms of bloodglucose level
cris Reply
It releases hormones from the pancreas insulin and glucagon
TONY
why human blood pressure high
amin Reply
fear, anxiety, sickness
Inemesit
why in mothers womb the foetus head is in anus direction?
Kick
As it seems the position downside n if we did such position thn soon we got vomiting then how foetus stay in downward position long time?
Kick
What is red blood cell
HANNAH Reply
A type of blood cell that is made in the bone marrow and found in the blood. Red blood cells contain a protein called hemoglobin, which carries oxygen from the lungs to all parts of the body. Checking the number of red blood cells in the blood is usually part of a complete blood cell (CBC) test. It
Noor
red blood cell are the most numerous blood cells.they comprise about 99% of all blood cells red blood cells are non nucleated it has red colour due to present to hemoglobin.
Vineeta
Thanks for the answers
HANNAH

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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