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By the end of this section, you will be able to:
  • Compare and contrast blood plasma, glomerular filtrate, and urine characteristics
  • Describe the characteristics of a normal urine sample, including normal range of pH, osmolarity, and volume

The urinary system’s ability to filter the blood resides in about 2 to 3 million tufts of specialized capillaries—the glomeruli—distributed more or less equally between the two kidneys. Because the glomeruli filter the blood based mostly on particle size, large elements like blood cells, platelets, antibodies, and albumen are excluded. The glomerulus is the first part of the nephron, which then continues as a highly specialized tubular structure responsible for creating the final urine composition. All other solutes, such as ions, amino acids, vitamins, and wastes, are filtered to create a filtrate composition very similar to plasma. The glomeruli create about 200 liters (189 quarts) of this filtrate every day, yet you excrete less than two liters of waste you call urine.

Characteristics of the urine change, depending on influences such as water intake, exercise, environmental temperature, nutrient intake, and other factors ( [link] ). Some of the characteristics such as color and odor are rough descriptors of your state of hydration. For example, if you exercise or work outside, and sweat a great deal, your urine will turn darker and produce a slight odor, even if you drink plenty of water. Athletes are often advised to consume water until their urine is clear. This is good advice; however, it takes time for the kidneys to process body fluids and store it in the bladder. Another way of looking at this is that the quality of the urine produced is an average over the time it takes to make that urine. Producing clear urine may take only a few minutes if you are drinking a lot of water or several hours if you are working outside and not drinking much.

Normal Urine Characteristics
Characteristic Normal values
Color Pale yellow to deep amber
Odor Odorless
Volume 750–2000 mL/24 hour
pH 4.5–8.0
Specific gravity 1.003–1.032
Osmolarity 40–1350 mOsmol/kg
Urobilinogen 0.2–1.0 mg/100 mL
White blood cells 0–2 HPF (per high-power field of microscope)
Leukocyte esterase None
Protein None or trace
Bilirubin <0.3 mg/100 mL
Ketones None
Nitrites None
Blood None
Glucose None

Urinalysis (urine analysis) often provides clues to renal disease. Normally, only traces of protein are found in urine, and when higher amounts are found, damage to the glomeruli is the likely basis. Unusually large quantities of urine may point to diseases like diabetes mellitus or hypothalamic tumors that cause diabetes insipidus. The color of urine is determined mostly by the breakdown products of red blood cell destruction ( [link] ). The “heme” of hemoglobin is converted by the liver into water-soluble forms that can be excreted into the bile and indirectly into the urine. This yellow pigment is urochrome    . Urine color may also be affected by certain foods like beets, berries, and fava beans. A kidney stone or a cancer of the urinary system may produce sufficient bleeding to manifest as pink or even bright red urine. Diseases of the liver or obstructions of bile drainage from the liver impart a dark “tea” or “cola” hue to the urine. Dehydration produces darker, concentrated urine that may also possess the slight odor of ammonia. Most of the ammonia produced from protein breakdown is converted into urea by the liver, so ammonia is rarely detected in fresh urine. The strong ammonia odor you may detect in bathrooms or alleys is due to the breakdown of urea into ammonia by bacteria in the environment. About one in five people detect a distinctive odor in their urine after consuming asparagus; other foods such as onions, garlic, and fish can impart their own aromas! These food-caused odors are harmless.

Questions & Answers

master gland Kon si h
kajal Reply
Pituitary gland
pituitary gland because it give harmonies and control other gland
glands often secrete hormones which play an important role in maintaining homeostasis.
pituitary gland
pituitary gland is master gland because it present in biran and secrtehormones and play other gland of human body and function its gland so that also called master gland.
pituitary glandis the master gland of our body
how do you study for A&P? lab and lecture?
Aubrey Reply
When one is suffering from motion sickness what area of the brain may trigger emesis?
amy Reply
that is the sign of stroke. if the patient have a stroke. the left side of body is weakness, the affected right of cerebrum but if right side of the body is weakness surely in left side!
thank you sooo much bro
Fatima Reply
Fatima hw a u
any one elaborate fr me foramens of the skull and features which they transmit
icant undrestand plz
zahruuzh Reply
try to read I hop you will understand
state and explain 20 radiology uses
what are chemicals in anatomy and physiology?
Mike Reply
what can I do to find it easy for me in anatomy and physiology course
study up on the basics of the periodic chart, learn bones and muscles attachments, and learn muscles. Those take the longest to memorize. After that it should be a little easier.
what are the two types of body cells
Jennifer Reply
what is malnutrition
malnutrition refers to faulty nutrition resulting from malabsorption,poor diet or overeating. Sometimes too these food do not contain all the six food nutrients in their right proportion.
thank you
Will u be malnourished?
What's the difference between radiology and radiology
Nothing! Radiology it means the study or using of radiation in medical science it can be 1.diagnose or treatment diagnosed radiology! x- ray. ultrasound. ct-scan. mammogram. MRI. 2. treatmen- radiation oncology, like Cobalt 60. and nuclear medicine
what is X-ray?
X-ray is type of light that make it possible to see inside any object. as human body
How the nervous system develops
ayiesher Reply
From the cells at the back of an embryo
breifly explain anatomy of thorax
Hadiza Reply
How many region the rib is divided
how many bon of human being
how to study for the skeletal system
and anatomy
I really need sources immediately
I printed out all the different bones. Put them in the see through protective sheaths and got dry erase markers. I could right on them and erase to help me learn to spell the names of markings and bones.
Or go to a book store, Barnes and Noble(doesn't have to be this) and they have coloring books for anatomy. $16. Really helpful.
okay thanks and are what study tools you use to study the materials and get a better understanding
*what are
I prefer diagrams, pictures that lay out each step with the information in each step. For Example: how action potential creates muscles to move. A pictured diagram gives me a better understanding of how each piece plays a role in each step of the process.
Also for basics, such as memorizing vocab. Flash cards are great. Don't become discouraged if you don't get them all right the first times through. The more you go through them, your brain will remember pieces of information from each and help you to pull out the information 😉
okay thanks
what is the functions of the lips in human
Momboi Reply
could I say sensation?
for protection
Lips assist in speech and eating
Too many easy questions. Which bones are the axial and appendicular? What are the abbreviations for TEE, TTE, AED, A-Mode, B-Mode, and LTH? What is the difference between hypothalamus and thalamus? Where is the parathyroid located? How many True Ribs do we have?
Sovilace Reply
Transesophageal echocardiography Transthoracic Echocardiography automated external defibrillator brightnees mode Los Hermanos Taverna
what is anatomy
okello Reply
anatomy is scientific study of body structures and how they relate to each other
Are there other functions of the nucleolus apart from synthesis of RNA and formation of ribosomes
Peninah Reply
plays a role in cell response to stress
what is angle of auscultation
Bryan Reply

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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