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Internal respiration

Internal respiration is gas exchange that occurs at the level of body tissues ( [link] ). Similar to external respiration, internal respiration also occurs as simple diffusion due to a partial pressure gradient. However, the partial pressure gradients are opposite of those present at the respiratory membrane. The partial pressure of oxygen in tissues is low, about 40 mm Hg, because oxygen is continuously used for cellular respiration. In contrast, the partial pressure of oxygen in the blood is about 100 mm Hg. This creates a pressure gradient that causes oxygen to dissociate from hemoglobin, diffuse out of the blood, cross the interstitial space, and enter the tissue. Hemoglobin that has little oxygen bound to it loses much of its brightness, so that blood returning to the heart is more burgundy in color.

Considering that cellular respiration continuously produces carbon dioxide, the partial pressure of carbon dioxide is lower in the blood than it is in the tissue, causing carbon dioxide to diffuse out of the tissue, cross the interstitial fluid, and enter the blood. It is then carried back to the lungs either bound to hemoglobin, dissolved in plasma, or in a converted form. By the time blood returns to the heart, the partial pressure of oxygen has returned to about 40 mm Hg, and the partial pressure of carbon dioxide has returned to about 45 mm Hg. The blood is then pumped back to the lungs to be oxygenated once again during external respiration.

Internal respiration

This diagram details the pathway of internal respiration. The exchange of oxygen and carbon dioxide between a red blood cell and a tissue cell is shown.
Oxygen diffuses out of the capillary and into cells, whereas carbon dioxide diffuses out of cells and into the capillary.

Everyday connection

Hyperbaric chamber treatment

A type of device used in some areas of medicine that exploits the behavior of gases is hyperbaric chamber treatment. A hyperbaric chamber is a unit that can be sealed and expose a patient to either 100 percent oxygen with increased pressure or a mixture of gases that includes a higher concentration of oxygen than normal atmospheric air, also at a higher partial pressure than the atmosphere. There are two major types of chambers: monoplace and multiplace. Monoplace chambers are typically for one patient, and the staff tending to the patient observes the patient from outside of the chamber ( [link] ). Some facilities have special monoplace hyperbaric chambers that allow multiple patients to be treated at once, usually in a sitting or reclining position, to help ease feelings of isolation or claustrophobia. Multiplace chambers are large enough for multiple patients to be treated at one time, and the staff attending these patients is present inside the chamber. In a multiplace chamber, patients are often treated with air via a mask or hood, and the chamber is pressurized.

Hyperbaric chamber

This photo shows two hyperbaric chambers.
(credit: “komunews”/flickr.com)

Hyperbaric chamber treatment is based on the behavior of gases. As you recall, gases move from a region of higher partial pressure to a region of lower partial pressure. In a hyperbaric chamber, the atmospheric pressure is increased, causing a greater amount of oxygen than normal to diffuse into the bloodstream of the patient. Hyperbaric chamber therapy is used to treat a variety of medical problems, such as wound and graft healing, anaerobic bacterial infections, and carbon monoxide poisoning. Exposure to and poisoning by carbon monoxide is difficult to reverse, because hemoglobin’s affinity for carbon monoxide is much stronger than its affinity for oxygen, causing carbon monoxide to replace oxygen in the blood. Hyperbaric chamber therapy can treat carbon monoxide poisoning, because the increased atmospheric pressure causes more oxygen to diffuse into the bloodstream. At this increased pressure and increased concentration of oxygen, carbon monoxide is displaced from hemoglobin. Another example is the treatment of anaerobic bacterial infections, which are created by bacteria that cannot or prefer not to live in the presence of oxygen. An increase in blood and tissue levels of oxygen helps to kill the anaerobic bacteria that are responsible for the infection, as oxygen is toxic to anaerobic bacteria. For wounds and grafts, the chamber stimulates the healing process by increasing energy production needed for repair. Increasing oxygen transport allows cells to ramp up cellular respiration and thus ATP production, the energy needed to build new structures.

Chapter review

The behavior of gases can be explained by the principles of Dalton’s law and Henry’s law, both of which describe aspects of gas exchange. Dalton’s law states that each specific gas in a mixture of gases exerts force (its partial pressure) independently of the other gases in the mixture. Henry’s law states that the amount of a specific gas that dissolves in a liquid is a function of its partial pressure. The greater the partial pressure of a gas, the more of that gas will dissolve in a liquid, as the gas moves toward equilibrium. Gas molecules move down a pressure gradient; in other words, gas moves from a region of high pressure to a region of low pressure. The partial pressure of oxygen is high in the alveoli and low in the blood of the pulmonary capillaries. As a result, oxygen diffuses across the respiratory membrane from the alveoli into the blood. In contrast, the partial pressure of carbon dioxide is high in the pulmonary capillaries and low in the alveoli. Therefore, carbon dioxide diffuses across the respiratory membrane from the blood into the alveoli. The amount of oxygen and carbon dioxide that diffuses across the respiratory membrane is similar.

Ventilation is the process that moves air into and out of the alveoli, and perfusion affects the flow of blood in the capillaries. Both are important in gas exchange, as ventilation must be sufficient to create a high partial pressure of oxygen in the alveoli. If ventilation is insufficient and the partial pressure of oxygen drops in the alveolar air, the capillary is constricted and blood flow is redirected to alveoli with sufficient ventilation. External respiration refers to gas exchange that occurs in the alveoli, whereas internal respiration refers to gas exchange that occurs in the tissue. Both are driven by partial pressure differences.

Questions & Answers

Hi everyone, Why actyl choline decreases blood pressure although it affects adrenal gland leading it to secret adrenaline and noradrenaline which increase blood pressure?
cholinergic receptors are mostly under Parasympathetic response while adrenergic (norepinephrine) receptors are mostly sympathetic although they are cholinergic adrenergic receptors as well
vocal cords
MT Reply
musah was admitted to your ward yesterday with traumatic amputation of the right thump . he complained this morning that he has not passed enough urine. Questions. 1) will you consider his complain to be pathological or physiological?. 2) in less than three sentences, justify your opinion. 3) Apply your understanding of the renin- angiotensin-aldosterone system to explain the factors and mechanisms accounting for his complains.
Ellen Reply
the mineral salt which break up a large portion of bone tissue is
Aurora Reply
please I need help. musah was admitted to your ward yesterday with traumatic amputation of the right thump. he complained this morning that he has not passed enough urine. Questions. 1). will you consider his complain to be pathological or physiological?.
2). In less than three sentences, justify your opinion.
cholesterol and triglycerides in simplest terms are fats (lipid) found in blood
Roy Reply
calcium is important for bone density and development. it also helps for safe / normal blood clotting, blood circulation to and from the heart, and muscle movement
what is muscle tissue
Rifat Reply
the muscle tissue is one of the 4 basic tissues in our body and is responsible for movement of our body
What Is difference between Ovary and Ovum
ovary is female reproductive organ while ovum is a female gamete formed from ovary
Thank You
What Is Cholesterol and Triglycerides
the mineral salt which break up a large portion of bone tissue
in simple way muscle tissue is responsible for movement of our body.
Hi Be Home Be safe , how are things doing hope all is well
Natarajan Reply
3 longitudinal bands of smooth muscles found in large intestines
what's is sutures
Nimeshka Reply
what would I like to know
Roy Reply
anything u can tell me
anatomy mins
when two or more bones meet.
I am interested in learning but it is a little threatening corona virus covid 19
Samnang Reply
I don't know about Corona virus
what would you like to know?
what is a peripheral protien
Ayesha Reply
actually its located in between the lipid layer, it does not specify if it's closer to the inside or the outside of the cell
It is protein found in lipid bilayer but found attached with Cytoplasm aspect
what are the collection of blood.?
sunshine Reply
Effect of exercise on different body systems?
Rania Reply
what is ambroylogy
kashif Reply
embryology..is the biological studing of embryos
I know biological study but embryology mean any pic, example?
I like to learn about medical and more
what is the function of the blood
Yolanda Reply
Transporting of oxygen,fighting against germs, forms clotting ,distribution of nutrients and minerals through out the body ,
Transportation of gases such as oxygen and water blance and carrei metabolites to the exit organ and Acid base equilibrium and clotting blood and Immune

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Source:  OpenStax, Anatomy & Physiology. OpenStax CNX. Feb 04, 2016 Download for free at http://legacy.cnx.org/content/col11496/1.8
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